the only time I purposely select cold wash is when I do a cold prewash on my whites with Biz. then I do a hot water wash. I haven't used chlorine bleach in years. Until sometime this year, I'd been using Sears HE Stain Fighter formula. Back in the spring sometime I switched to Tide HE (and then the new with bleach HE) when I could get my hands on it for whites, my light colored sheets, and lighter colored towels. I have two 120 load boxes of Cheer HE I got from Sams and started using one of them last weekend (had to finish the Sears Ultraplus). I have somewhat sensitive skin and as long as I wash my hands after putting in the dosage of detergent, my hads don't break out and crack on the skin. Have ha no problems on my body either, but the extra rinse and washing in a front loader period probably help with that. I did have problems growing up with irritation with Tide being used, but then there was no 2nd rinse or it wasn't used when it was available when my mom did laundry. Whites (undes kitchen stuff); towels, and sheets are done in hot water 120 degrees or more. My flannel sheets are washed in warm. And I will also add, I did boil some whites with boiling water added through the dtergent dispenser) last spring (and I believe Id ocumented it here), which ended up having stains removed that had been set in. So that proved to me even hotter water washes even better for whites.