The master bed/bath in my home was added on back in the 60's or 70's, long before I bought it. It's south facing and has the tallest part of the crawl space. And the heating ducts are bit undersized. As a result it tends to get hotter in summer and colder in winter than the rest of the house. Not a lot, just a few degrees, but noticeable.
I've been considering getting one of the portable A/C units that features a heat pump as well, so it could be used year-round in the master bedroom, and not block up much of a window. So far, however, I haven't found one with a dual hose setup, which would be the most efficient way to go, I think.