arbilab
Well-known member
Deluged by (sometimes vulgar/rude) commercials for the latest hit prescriptable from Big Pharm, found a cynical giggle here and there. I mean, besides the usual ones like sudden death as a side effect of toenail-fungus ointment. Feature I suppose, as compared to lingering death.
Might could tell, I'm uber-skeptical of Big Pharm. From their snakeoil roots to their dubious ethics and ubiquitous marketing which was illegal until 1985 and metastasized in 1997 with constraints lifted. Ask your doctor if Fixyourightupacin is right for you? I'd think thrice.
First installment, we were already talking about dextromethorphan (DXM) in cough syrups and pills and how inappropriate/undesirable that may be. It pops up as the co-active in a pill for pseudobulbar affect, which tends toward association with amyotrophic lateral- and multiple- sclerosis. What does that have to do with postnasal drip/coughing? That's the punch line we'll get to in a second.
Nuedexta combines DXM with quinidine, used for arrhythmia and malaria, to help the pseudobulbar-affected stop giggling. OK, if that's what FDA says, and they do. Turns out, the DXM is the active and the quinidine just happens to enhance its bioavailability. In Nuedexta, DXM is at twice the mg/dose as in cough syrup. DXM is categorized as a 'dissociant', meaning it sorta disconnects your brain from the world and can be abused as such. It also tinkers with serotonin, and do you really want that tinkered?
Speaking of serotonin, I have been a little grumpier since I switched away from DXM syrup. But that could also be caused by an hour of CNN.
Back to DXM as a cough/allergy remedy. At which it's tied with placebo for efficacy. Worse, one of its side effects is histamine release. Wait, that's what we were trying to stop! And sure enough, one of the side effects of Nuedexta is------ coughing. And the discount price for these extended-action cough pills equivalent to a double dose of $3 kiddy cough syrup? $20 each, $40/day.
Sorry about the syllabic proliferation but it's the language of Pharm. To an extent I suppose it needs to be, but I'm sure they embrace the side effect of stopping people from attempting to read the grimy details of what's in these gawldang-fangled dagflabbed PILLS.
[this post was last edited: 9/20/2018-23:28]
Might could tell, I'm uber-skeptical of Big Pharm. From their snakeoil roots to their dubious ethics and ubiquitous marketing which was illegal until 1985 and metastasized in 1997 with constraints lifted. Ask your doctor if Fixyourightupacin is right for you? I'd think thrice.
First installment, we were already talking about dextromethorphan (DXM) in cough syrups and pills and how inappropriate/undesirable that may be. It pops up as the co-active in a pill for pseudobulbar affect, which tends toward association with amyotrophic lateral- and multiple- sclerosis. What does that have to do with postnasal drip/coughing? That's the punch line we'll get to in a second.
Nuedexta combines DXM with quinidine, used for arrhythmia and malaria, to help the pseudobulbar-affected stop giggling. OK, if that's what FDA says, and they do. Turns out, the DXM is the active and the quinidine just happens to enhance its bioavailability. In Nuedexta, DXM is at twice the mg/dose as in cough syrup. DXM is categorized as a 'dissociant', meaning it sorta disconnects your brain from the world and can be abused as such. It also tinkers with serotonin, and do you really want that tinkered?
Speaking of serotonin, I have been a little grumpier since I switched away from DXM syrup. But that could also be caused by an hour of CNN.
Back to DXM as a cough/allergy remedy. At which it's tied with placebo for efficacy. Worse, one of its side effects is histamine release. Wait, that's what we were trying to stop! And sure enough, one of the side effects of Nuedexta is------ coughing. And the discount price for these extended-action cough pills equivalent to a double dose of $3 kiddy cough syrup? $20 each, $40/day.
Sorry about the syllabic proliferation but it's the language of Pharm. To an extent I suppose it needs to be, but I'm sure they embrace the side effect of stopping people from attempting to read the grimy details of what's in these gawldang-fangled dagflabbed PILLS.
[this post was last edited: 9/20/2018-23:28]