My home has air returns in all three bedrooms, the living room, the upstairs hallway and the kitchen. Only the bathrooms and the laundry (which contains the furnace) lacks return air. Ironically, the very HVAC company I now work for installed my HVAC when my house was built in 2004, nine years before I bought it and eight years before I started working for the company.
When my company does a new install, we insist on having multiple return-air inlets throughout the home, ideally in each bedroom in addition to the living room, dining room, etc. It really helps with efficiency, equalizing indoor temps, proper dehumidification when running the AC and much better indoor air quality.
We actually take the time to calculate for the optimal balance of supply and return. You want to have about the same CFM for supply and return. We factor in the blower CFM of the furnace or AHU, and even factor in frictional losses that system components impose (everything from registers to dampers to the air cleaner to the linear run of the system, including bends) to get the proper size of the trunks (the main run for supply and return).
Based on what I've seen in existing installs when doing a repair or replacement, a lot of HVAC contractors seem to only size the equipment, sometimes you're lucky if they even do that properly. The distribution seems to be an afterthought in a lot of cases.