It is possible to have one system that can accommodate different exposures by using an electronic damper system. I recently did a major, down-to-the studs remodel and addition to a house which has four very different exposures. Finding room for four different systems would have been exceedingly difficult, so the house was equipped with two systems, one of which has a three zone damper.
The living room and kitchen are on the simple system without the damper, so these rooms are either both heated or cooled according to the demands of the thermostat. The second system has three thermosats and three zones, with the zones being a rec room, the master suite, and two secondary bedrooms with their bathroom. The master suite tends to be the hottest zone, with large south facing windows, while the rec room is built into a hillside and thus the coolest. With the damper, if the rec room needs heat in the morning but the master suite thermostat sends a call for cooling, the system will keep the furnace on until the rec room is satisfied but it will shunt all the heat into that room. Once it is hot enough, the furnace will turn off and blow ambient air through the ducts to exhaust the heat. Then the dampers will switch the air handler's output to the master suite and start the air conditioning cycle, which will continue until that room's thermostat is satisfied. If the secondary bedrooms need heating or cooling they can share in either cycle, or if all rooms need heating or cooling at the same time they can all share the cycle. The system has a variable speed compressor and fans to deal with the varying loads. It works very well if designed and sized correctly and only adds a few thousand to the price of the system, much less than having lots of separate systems.