He even directed most of the Frankie=Annette beach movies of the early to mid 1960s.
The director of I Love Lucy for the first season was Marc Daniels. He left after one season to take a job that paid more:
http://en.wikipedia.org/wiki/Marc_Daniels
probably unaware that anyone involved with the program would be going on to make history. Asher then directed three or four more seasons. James V. Kern directed most of season five and some of six, but I believe Asher was brought back to direct the last portion of season six.
FYI I Love Lucy ran 1951-1957 as a weekly show, and there are six seasons of episodes. For 1957-1960, they did three seasons of "The Lucy-Desi Comedy Hour" which aired only once per month, but was an hour in length. Same characters and plot (they continued living in Westport, CT, which is where the sixth season of I Love Lucy had concluded), making heavy use of celebrity guest stars (Danny Thomas, Tallulah Bankhead, Ernie Kovacs, Bob Cummings, Harry James/Betty Grable, etc.). The weekly one hour time slot was filled with Desilu-produced dramatic anthologies on "off weeks" when there was no Lucy-Desi episode.
During the final season, 1959-1960, only three episodes were made, and Lucille Ball filed for divorce the day after filming of the last episode had concluded. Part of the novelty of the show was that a show business couple in real life portrayed a show business couple (well, a would-be show business wife married to a show business husband) on tv. Their Westinghouse contract specified that they would remain married in real life. Ball had contemplated divorce earlier, but friends and her attorney advised that they might be in breach of contract if they divorced before the Westinghouse contract expired (the final episode was broadcast after she filed for divorce, but filming was completed before she went to court).