depends on the bulk of the load.....and of course the machine......
I have quilts, not puffed comforters.....so for example in the FL Neptunes, yeah, I would wash the whole bedding(quilt, sheets, and pillowcases) in one load, wether if it was a king, queen, or twin size...
this same thing would fit in the SQ just the same....granted not all machines can handle this type of load well...