What is the Best way that you have found to remove paint from clothes

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Hairspray usually works. Spray it on, rub a little with a rag or your fingernail. As it loosens, repeat. Then launder as usual.

Goof Off also works well, but hairspray usually gets it.
 
Probably depends on the paint. Water based latex, and oil-based paints probably have different methods needed.

For latex, try something like Goof-off.

For oil based, probably a paint thinner.
 
Burn the clothes.

Personally I only wear clothes that ready for the (garbage) bin, because IMHO you can't get rid of the paint--especially after it dries.
 
When painting, it's best to wear old clothes anyway. These generally shed the least lint, because it's been washed out of them.

This is especially true when finishing flooring (with varnish etc).
 
Obviously,

It is best to never get paint on good clothes to begin with...but...just two weeks ago, the jerk at Home Depot didn't put the lid on the (expensive) can of paint he mis-matched and the damn thing came off as I was walking down the stairs...and it splashed over a brand new coat and perfectly good jeans.

PineSol, rubbed into the dratted stuff liberally and then washed in warm water with borax got rid of it.

This was an acrylic based paint, for what it's worth. I don't think you can get polyurethane or epoxy out with anything.
 
See if you can get something like "Decorators Wipes".

They're like WetOnes baby wipes, but they are moistened with some kind of solvents which will remove paint, oil and silicone.

Make sure that the garment is 100% dry and that it has no traces of the wipe residue before washing in a machine.

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